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KMID : 0616120070380030245
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 3 p.245 ~ p.253
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Hepatoprotective Effect of Fermented Artemisia princeps PAMPANINI by Lactic Acid Bacteria
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Choi Hyuck-Jai
Kim Eun-Jin
Kim Nam-Jae
Kim Dong-Hyun
Han Myung-Joo
Baek Nam-In
Chung Hae-Gon
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Abstract
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Artemisia princeps PAMPANINI has been used in traditional medicine of the treatment of inflammatory, liver dysfunction and order disorder in the far east countries including Korea. The present study was carried out to investigate the hepatoprotective effects of ethanol extract of Artemisia princeps (AP) and its fermented agents (AP-F) by lactic acid bacteria derived from human intestinal bacteria on liver injured rat induced by CCl4 and d-galactosamine. Hepatoprotective activity was monitored by estimating serum ALT, AST, ALP, LDH, superoxide dismutase (SOD), glutathione redeuctase (GR) and glutathione peroxidase (Gpx) activities in the liver injured by hepatotoxin. Pretreating rats with AP or AP-F at the same dosage regimen significantly suppressed the acute elevation of serum transaminase, ALP, LDH and GR activities, and significantly increased the lowering of blood SOD and GR activites induced by hepatoxin. Based on these findings, it is presumed that AP and APF may have the hepatoprotective effect on CCl4 and d-galactosamine-induced hepatotoxicity rat.
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KEYWORD
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Artemisia princeps PAMPANINI, Fermented Artemisia, lactic acid bacteria, hepatoprotective, transaminase, antioxidative
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